[פירוט] בקשר למה שרשום בנעוץ על קפאין וקריאטין

[airwolf67]

יש מספר חומרים אשר אינטרקציה שלהם עם קפאין עלולה להתנגש או לשפר את השפעתו.
קפאין ו-לקרניטין ביחד משפרים את הסיבולת ומאריכים את זמן המאמץ, כמו יש מקורות אשר
ימליצו לשלב קפאין ואפדרין לסוגי אימון שונים.

הנושא של האם לקחת קפאין וקריאטין ביחד שנוי במחלוקת, 2 מחקרים שהיו בנושא אומרים
שהם נוגדים זה את זה, ומחקר אחר שהיה בנושא אומר שיש להם אפקט חיובי על זמן ההתאוששות
של השריר, עם זאת החשיבות של ההשפעה עדיין לא נקבעה.

עוד מחקר שבוצע בנושא הראה שכאשר נלקחו ביחד מעל 6 ימים, הקפאין מנע את האפקט של הקריאטין,
ומצד שני צריכת קפאין לפני אימון בזמן תקופת העמסת קריאטין,עדיין שומרת על ביצועים אתלטיים.

זה מראה שצריכת קפאין עלולה לפגום בהשפעות של הקריאטין, אך צריכת קראטין לא פוגמת בהשפעותיו
שהושגו ע"י הקפאין.

למרבה הצער עדיין אין מספיק חומר כדי להסיק מסקנות זה מוטל בספק שקפאין מונע לגמרי את
השפעותיו של הקריאטין משום שקריאטין פועל בכמה דרכים אך מה שלא יהיה ברור שקריאטין
לבד ישפיע יותר טוב כשלא נלקח עם קפאין.

זה נכון? אפשר הסבר טוב יותר? האם יש חידושים בנושא? אפשר לקרוא אותם בבקשה...

תודה

[Moshe]

The thermogenic properties of ephedrine/methylxanthine mixtures: human studies.

Dulloo AG, Miller DS.
The thermogenic effect of an over-the-counter preparation containing 22 mg ephedrine, 30 mg caffeine and 50 mg theophylline was investigated in human volunteers with a predisposition to obesity and also in the lean. The ephedrine/methylxanthines mixture was twice as effective as ephedrine alone in increasing the fasting metabolic rate of both subject groups, and it normalized the reduced thermogenic response to a 1.25-MJ meal observed in those predisposed to obesity. Measurements of 24-h energy expenditure in a respirometer indicate that the mixture had no effect on the daily metabolic rate of the lean, but was effective in causing a significant 8 percent increase in the 24-h energy expenditure of those subjects predisposed to obesity. These studies indicate that relatively mild doses of dietary methylxanthines in combination with ephedrine can raise daily energy expenditure of those predisposed to obesity, mainly by correcting their defective thermogenic response to food. Such ephedrine/methylxanthine preparations could be useful as aids in the treatment of obesity.


The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial.

Astrup A, Breum L, Toubro S, Hein P, Quaade F.
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Copenhagen, Denmark.
The sympathomimetic agent ephedrine has potent thermogenic and anti-obesity properties in rodents. The effect is markedly enhanced by caffeine, while caffeine given alone has no effect. This study was undertaken to find out if a similar weight reducing synergism between ephedrine and caffeine is present in obese patients. In a randomized, placebo-controlled, double blind study, 180 obese patients were treated by diet (4.2 MJ/day) and either an ephedrine/caffeine combination (20mg/200mg), ephedrine (20 mg), caffeine (200 mg) or placebo three times a day for 24 weeks. Withdrawals were distributed equally in the four groups, and 141 patients completed the trial. Mean weight losses was significantly greater with the combination than with placebo from week 8 to week 24 (ephedrine/caffeine, 16.6 +/- 6.8 kg vs. placebo, 13.2 +/- 6.6 kg (mean +/- s.d.), P = 0.0015). Weight loss in both the ephedrine and the caffeine groups was similar to that of the placebo group. Side effects (tremor, insomnia and dizziness) were transient and after eight weeks of treatment they had reached placebo levels. Systolic and diastolic blood pressure fell similarly in all four groups. We conclude, that in analogy with animal studies, the ephedrine/caffeine combination is effective, while caffeine and ephedrine separately are ineffective for the treatment of human obesity.


Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture.

Toubro S, Astrup AV, Breum L, Quaade F.
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Fredriksberg, Copenhagen, Denmark.
In a randomized, placebo-controlled, double blind study, 180 obese patients were treated by diet (4.2 MJ/day) and either an ephedrine/caffeine combination (20mg/200mg), ephedrine (20mg), caffeine (200mg) or placebo 3 times a day for 24 weeks. 141 patients completed this part of the study. All medication was stopped between week 24-26 in order to catch any withdrawal symptoms. From week 26 to 50, 99 patients completed treatment with the ephedrine/caffeine compound in an open trial design, resulting in a statistically significant (p = 0.02) weight loss of 1.1kg. In another randomized, double-blind, placebo-controlled 8 week study on obese subjects we found the mentioned compound showed lean body mass conserving properties. We conclude that the ephedrine/caffeine combination is effective in improving and maintaining weight loss, further it has lean body mass saving properties. The side effects are minor and transient and no withdrawal symptoms have been found.


Thermogenic synergism between ephedrine and caffeine in healthy volunteers: a double-blind, placebo-controlled study.

Astrup A, Toubro S, Cannon S, Hein P, Madsen J.
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Animal and human studies have suggested a thermogenic synergism between ephedrine (E), a beta-agonist, and caffeine (C), an adenosine antagonist, which may be suitable for the treatment of obesity. To study this phenomenon, the thermogenic effect of single doses of oral placebo, E 10 mg, E 20 mg, C 100 mg, and C 200 mg were compared with the effects of three different combinations of E + C, 10 mg/200 mg, 20 mg/100 mg, and 20 mg/200 mg, measured by indirect calorimetry in six healthy, lean subjects. The thermogenic effect after E + C 20 mg/200 mg was larger than that of any of the other combinations. In this dose ratio, ephedrine and caffeine exerted a supra-additive synergism, whereas the thermogenic effects of the other two combinations were only additive. The 3-hour postintake increase in systolic blood pressure after all three combinations averaged 5 to 7 mm Hg more than placebo (P less than .01), which exceeded the predicted additive effect fivefold to sevenfold. Diastolic blood pressure was not increased by E + C 20 mg/200 mg, whereas the other two combinations increased it by approximately 4 mm Hg more than placebo. E + C 20 mg/100 mg and 20 mg/200 mg increased heart rate more than placebo, while E + C 10 mg/200 mg had no effect on heart rate. As expected, all combinations increased plasma glucose, insulin, and C-peptide from their ephedrine content. No significant effects of the combinations were found on plasma lactate, glycerol, nonesterified fatty acids (NEFA), triglyceride, potassium, or sodium.(ABSTRACT TRUNCATED AT 250 WORDS)




בקשר לקריאטין וקפיאין אכן יש 2 מחקרים כאלו ואחד שסותר אותם , לא הייתי ממהר להסיק מסקנות נדרש עוד מחקר

[airwolf67]

אפדרין ממכר?
מאיפה קנית? כמה אמור לעלות?
תודה

[Moshe]

לך לבחור הגדול במכון כושר הוא יסדר אותך , מחיר שוק 50 מ"ג - 5 שקל , לא לעבור את ה75 מ"ג אפדרין ביום מחולק 3 מנות עם 200 מ"ג קפיאין כל מנה.